Treatment-resistant ulcerative necrobiosis lipoidica in a diabetic patient responsive to ustekinumab
نویسندگان
چکیده
منابع مشابه
Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: case report and proposed mechanism.
We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient's disease course and elaborate upon mechanistic reasons for her improvement related to ustekinuma...
متن کاملNecrobiosis Lipoidica
Background: In 1929, Oppehhein first described necrobiosis lipoidica diabeticorum and called it dermatitis atrophicans lipoidica diabetica, but it was later renamed necrobiosis lipoidica diabeticorum (NLD) by Urbach in 1932. In 1935, Goldsmith reported the first case in a nondiabetic patient. Other cases of NLD in nondiabetic patients were described by Meischer and Leder in 1948. Rollins and Wi...
متن کاملNecrobiosis lipoidica
A 47-year-old woman reported an 18-month-old pretibial rash on her left shin during a routine office visit. She had a history of type 1 diabetes mellitus (DM) and has been on insulin therapy for the past 13 years. She did not complain of any itching, pain, or bleeding from the rash. On examination, an 8 3 cm elongated indurated plaque with telangiectases, central atrophy, and yellow pigmentatio...
متن کاملSuccessful treatment of ulcerative and diabeticorum necrobiosis lipoidica with intravenous immunoglobulin in a patient with common variable immunodeficiency.
Discussion |Threemuscles, thecircularorbicularis oris, depressor labii inferioris, andmentalis align the labiomental fold or cross it as they pass to their insertion.2 The fibers of the 3 muscles are attached to the skin by thick bands of fibroelastic fibers. Thementalismuscles originate from themandible and serve as paired elevators of the central lower lip.3 They usually overlap and insert in...
متن کاملSuccessful Treatment of Ulcerative and Diabeticorum Necrobiosis Lipoidica With Intravenous Immunoglobulin in a Patient With Common Variable Immunodeficiency
Discussion |Threemuscles, thecircularorbicularis oris, depressor labii inferioris, andmentalis align the labiomental fold or cross it as they pass to their insertion.2 The fibers of the 3 muscles are attached to the skin by thick bands of fibroelastic fibers. Thementalismuscles originate from themandible and serve as paired elevators of the central lower lip.3 They usually overlap and insert in...
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ژورنال
عنوان ژورنال: Dermatology Online Journal
سال: 2019
ISSN: 1087-2108
DOI: 10.5070/d3258045141